can you take semaglutide and then switch to tirzepatide Switching Tirzepatide: A Provider's Guide Switching from semaglutide to tirzepatide

Combined with a GLP-1 receptor agonist, it has a more significant effect on glucose and body weight effects

Evidence from Clinical Trials on Weight Loss and Body Composition Liraglutide-based clinical evidence from the SCALE (Satiety and Clinical Adiposity-Liraglutide Evidence) trials (NCT01272219 and NCT01272232), which included older adults within the adult study population, reported that a 56-week intervention with liraglutide 3 mg/day as an adjunct to lifestyle modification resulted in significant weight loss compared with placebo [41, 42]

The drug is a synthetic version of the venom's hormone, developed by scientists to mimic the effects of GLP-1, which boosts the body's ability to release its own insulin

doi: 10.1007/s11695-008-9547-2 114

PMC7817689 PMC / NIH Reynolds et al

Phase 3 TRIUMPH trial data on long-term discontinuation effects are still emerging as of 2026